A nostalgic look back 40 years after the discovery of receptor-mediated endocytosis

Receptor-mediated endocytosis.

Receptor - mediated endocytosis

In 1934, Lewis described the process ofpinocytosis an invagination of the plasma membrane enclosing a small droplet of fluid. Pinocytosis appeared to be a constitutive process, whereas phagocytosis described some years earlier by Metchnikoffwas regulated. Only within the last two decades has it been recognized that (i) during pinocytosis cells internalize vast amounts of membrane. indeed, more ...

Mechanics of receptor-mediated endocytosis.

Most viruses and bioparticles endocytosed by cells have characteristic sizes in the range of tens to hundreds of nanometers. The process of viruses entering and leaving animal cells is mediated by the binding interaction between ligand molecules on the viral capid and their receptor molecules on the cell membrane. How does the size of a bioparticle affect receptor-mediated endocytosis? Here, we...

Implementation intentions: a look back at fifteen years of progress.

Implementation intentions are if-then plans that spell out when, where, and how a set goal has to be put into action: If situation x is encountered, then I will perform behavior y!, thereby linking a critical situation with a goal-directed behavior. Over the last fifteen years, implementation intentions, as compared to simple goal intentions (I intend to reach z!), have demonstrated their effec...

Health law at fifty years: a look back.